More places are mixing vaccines, but do they need to?

By Jacqueline Howard, CNN

From Germany to the Dominican Republic, government health authorities are recommending the “mix-and-match” approach to vaccination in the hope of better protecting people by giving people them two different types of vaccine — one as a first dose, and another as a second or even a third dose.

But does it really protect people better, and is it even necessary? From a scientific point of view, the jury is still out.

Studies are currently underway to better understand the risks and benefits of mixing coronavirus vaccines — which might ease logistical problems for some global vaccine programs. But more research is needed to see whether mixed vaccine schedules work in the real world.

On Thursday, Germany issued what appears to be the strongest recommendation anywhere for the mixing of coronavirus vaccines.

The German Standing Committee on Vaccination (STIKO) said people who receive a first dose of the AstraZeneca vaccine “should get an mRNA vaccine as their second dose, regardless of their age.”

The Pfizer/BioNTech and Moderna coronavirus vaccines use mRNA technology, while AstraZeneca’s vaccine uses a virus called an adenovirus to deliver immune-generating instructions to the body.

STIKO said “current study results” show the immune response generated after a mixed dose vaccination “is clearly superior.”

The Dominican Republic said Thursday it would begin giving medical professionals a third, booster dose of vaccine to counter emerging coronavirus variants and said recipients should receive a different vaccine type from their first two doses. The country has been using three different vaccines: AstraZeneca’s, China’s Sinovac vaccine and the Pfizer/BioNTech vaccine.

In June, Canada’s National Advisory Committee on Immunization made a weaker recommendation when it said “an mRNA vaccine is now preferred as the second dose for individuals who have received a first dose of AstraZeneca/COVISHIELD vaccine.”

The Canadian committee said it was making the recommendation based on “emerging evidence of a potentially better immune response from this mixed vaccine schedule.”

Vaccine schedules that mix the Oxford/AstraZeneca and Pfizer Covid-19 vaccines all induced robust immune responses, although schedules including the Pfizer vaccine were stronger, researchers in the United Kingdom found.

In a separate study, people who got mixed doses of coronavirus vaccines — receiving a different vaccine type as a second dose than the first dose — appeared to be more likely to experience mild side effects such as fever, chills, fatigue or headache, researchers in the UK reported in May in the Lancet medical journal.

But the side effects following mix-and-match vaccinations were short-lived and there were no other safety concerns.

‘A research agenda to try and optimize vaccines’

The idea of using one type of vaccine for a first dose and a different type as the second has been explored for quite some time — even before the coronavirus pandemic, Dr. Amesh Adalja, senior scholar at the Johns Hopkins University Center for Health Security, told CNN on Friday. The concept is called heterologous prime-boost vaccination.

“There were studies in the past with bird flu viruses using heterologous prime-boost, and this is part of a research agenda to try and optimize vaccines,” Adalja said.

“It’s early in that research to understand where this will all end up several months to years from now in terms of what Covid vaccines will look like in the future. But it’s important to understand how to make better second-generation vaccines and to use this knowledge to even improve other vaccines for other infectious diseases,” Adalja added.

It’s important to understand how immune responses differ to different vaccines, Adalja said. The immune system responds in varying ways to different vaccine technologies.

“This is a very fruitful area of research that’s important to understand, and it may help to design better vaccine regimens, especially in people that might not necessarily respond as well to the standard regimens — for example, an immunosuppressed person who’s had a solid organ transplant,” he said.

One study, published in June in the journal Annals of Internal Medicine, suggests that a third dose of coronavirus vaccine could help boost antibody levels among some organ transplant recipients who have not had robust responses to the standard vaccination schedules.

Among patients in the study who had no measurable antibodies after receiving two doses of vaccine, one-third saw a rise in antibodies after a third dose — and among those with low antibody levels after two doses, all of them saw an increase after a third dose. Some were boosted with the same vaccine but many were not.

No need for boosters quite yet

With the more contagious Delta coronavirus variant circulating in the United States, some people worried whether an extra dose of vaccine would be needed to boost those who have been vaccinated — especially those who received the Johnson & Johnson coronavirus vaccine, which was perceived as potentially being less effective.

But newly released data suggest otherwise.

The Johnson & Johnson vaccine provides immunity that lasts at least eight months, and it appears to provide adequate protection against the worrying Delta variant, the company said in a statement Thursday night.

“Current data for the eight months studied so far show that the single-shot Johnson & Johnson COVID-19 vaccine generates a strong neutralizing antibody response that does not wane; rather, we observe an improvement over time,” Dr. Mathai Mammen, head of research and development at J&J’s Janssen vaccine arm, said in a statement.

The company said one dose of the vaccine elicits both a lasting antibody response and generates immune cells called T-cells that last eight months, also.

This suggests boosters are not needed at this time, Dr. Paul Offit, director of the Vaccine Education Center at the Children’s Hospital of Philadelphia, told CNN on Friday.

“We should be driven by the science,” Offit said. “Right now, the science tells us the two doses of the mRNA vaccine or a single dose of the Johnson & Johnson vaccine would protect you against severe critical disease caused by the Delta variant.”

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CNN’s Niamh Kennedy and Naomi Thomas contributed to this report.